Iridium-Catalyzed β-Alkynylation of Aliphatic Oximes as Masked Carbonyl Compounds and Alcohols
An Ir-catalyzed C(sp3)?H alkynylation of aliphatic ketones, aldehydes, and alcohols was achieved by using the corresponding oxime derivatives and a IrIII catalyst. This general reaction is selective towards primary C(sp3)?H bonds and can be used for the late-stage C?H alkynylation of complex molecules.
Echavarren, Antonio M.,Tan, Eric,Zanini, Margherita
Iridium-catalyzed intermolecular amidation of sp3 C-H bonds: Late-stage functionalization of an unactivated methyl group
Reported herein is the iridium-catalyzed direct amidation of unactivated sp3 C-H bonds. With sulfonyl and acyl azides as the amino source, the amidation occurs efficiently under mild conditions over a wide range of unactivated methyl groups with high functional group tolerance. This procedure can be successfully applied for the direct introduction of an amino group into complex compounds and thus can serve as a powerful synthetic tool for late-stage C-H functionalization.
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