- Synthetic method of docetaxel side chain
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The invention relates to a synthetic method of a docetaxel side chain, which comprises the following steps: by using (2R, 3S)-2-hydroxy-3-phenyl-3-(((S)-1-phenethyl)-amino)methyl propionate as a raw material, carrying out reduction reaction in the presence of palladium on carbon and hydrogen to obtain (2R, 3S)-3-phenyl isoserine methyl ester salt, and carrying out di-tert-butyl dicarbonate substitution reaction to obtain (2R, 3S)-3-t-butyloxycarboryl-2-hydroxy-3-Methyl 3-phenylpropionate; preparing (4S, 5R)-3-tert-butoxycarbonyl-2-(4-methoxy phenyl)-4-phenyl-5-oxazoline carboxylic acid methylester from through cyclization protection reaction, and finally hydrolyzing to obtain a docetaxel side chain crude product; and recrystallizing the crude product of the docetaxel side chain, and further purifying to obtain a finished product of the docetaxel side chain. The synthetic method disclosed by the invention is safe, environment-friendly, economical, efficient and suitable for large-scaleindustrial production.
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