Pteridin-4(3H)-ones and related compounds: Synthesis via intermolecular aza-Wittig reaction-heterocyclization and crystal structure
2,3-Disubstituted pteridin-4(3H)-one derivatives have been synthesized by the intermolecular aza-Wittig reaction-heterocyclization methodology. The structures of 3-allyl-2-anilinopteridin-4(3H)-one and 2-anilino-3-isopropylpteridin-4(3H)-one were determined by X-ray crystallographic analysis. Furthermore, imidazo[2,1-b]pteridine derivatives were synthesized by heterocyclization including iodoamination.
Methyl 3-(triphenylphosphoranylideneamino)pyrazine-2-carboxylate: Synthesis, crystal structure and use in pteridin-4(3H)-ones synthesis
The title iminophosphorane 6 has been prepared from methyl 3-aminopyrazine-2-carboxylate 1 by a modified Kirsanov method using a triphenylphosphine-hexachloroethane-triethylamine system. The crystal structure of 6 illustrated an iminophosphorane function (N=P bond). 2,3-Disubstituted pteridin-4(3H)-ones were obtained in a one-pot reaction of 6 with isocyanates, followed by heterocyclization on addition of alcohols or amines.
Okawa, Tomohiro,Eguchi, Shoji,Kakehi, Akikazu
p. 247 - 254
(2007/10/03)
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