- Tryptamine analogs with 5-HT1D selectivity
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Described herein are tryptamine analogs that display high binding affinity and selectivity for the 5-HT1Dβ receptor, of the formula: STR1 wherein R 1 represents a chain selected from C 8-11 alkyl, C 7-10 alkoxy, C 8-11 alkanoyl and C 7-10 alkanoyloxy wherein said chain is optionally substituted by hydroxyl, C 1-4 alkyl or C 1-4 alkoxy and wherein one of the intervening carbons of said chain is optionally replaced with a heteroatom selected from oxygen, nitrogen and sulfur;R 2 and R 3 each independently represent H or C 1-3 alkyl; andR 4 represents H, C 1-4 alkyl, aryl or arylC 1-4 alkyl;The compounds are useful as reagents for receptor identification and in receptor-based drug screening programs, and can also be used therapeutically to treat conditions for which administration of a 5-HT1D ligand is indicated, for example in the treatment of migraine.
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