15793-38-1

Basic information

• Product Name: Quinazosin
• Synonyms: Quinazosin;2-(4-Allyl-1-piperazinyl)-6,7-dimethoxyquinazolin-4-amine;4-QuinazolinaMine, 6,7-diMethoxy-2-[4-(2-propen-1-yl)-1-piperazinyl]-
• CAS NO: 15793-38-1
• Molecular Formula: C₁₇H₂₃N₅O₂
• Molecular Weight: 329.4
• Mol File: 15793-38-1.mol

Chemical Properties

• Boiling Point: 525.9°Cat760mmHg
• Flash Point: 271.9°C
• Appearance: /
• Density: 1.207g/cm³
• Vapor Pressure: 3.75E-11mmHg at 25°C
• Refractive Index: 1.616
• PKA: 7.24±0.10(Predicted)
• CAS DataBase Reference: Quinazosin(CAS DataBase Reference)
• NIST Chemistry Reference: Quinazosin(15793-38-1)
• EPA Substance Registry System: Quinazosin(15793-38-1)

Safety Data

• Hazardous Substances Data: 15793-38-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
QUINAZOSIN is used as an antihypertensive agent for the treatment of high blood pressure. It helps in managing and reducing the risk of cardiovascular diseases associated with hypertension by blocking the action of hormones on blood vessels, thus causing a decrease in blood pressure.
Used in Chemical Synthesis:
QUINAZOSIN is used as a valuable intermediate in the preparation of guanidines and other urea derivatives. These compounds are essential in the synthesis of various pharmaceutical products, contributing to the development of new medications and therapeutic agents.

InChI:InChI=1/C17H23N5O2/c1-4-5-21-6-8-22(9-7-21)17-19-13-11-15(24-3)14(23-2)10-12(13)16(18)20-17/h4,10-11H,1,5-9H2,2-3H3,(H2,18,19,20)

Related news

Leukocyte and bone marrow effects of a thiomorpholine Quinazosin (cas 15793-38-1) antihypertensive agent☆09/05/2019

PD-88823, a thiomorpholine analog of prazosin, induced a consistent dose-related suppression of granulopoiesis with subsequent neutropenia and leukopenia in rats and dogs. Rats treated at 600 mg kg−1 day−1 had neutrophil counts reduced by 44% in males and 30% in females after 13 weeks. A 4-week ...detailed

Relevant articles and documents

Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives

6,7-Dimethoxy-4-amino-2-(4-substituted piperazin-1-yl)-quinazolines and 6,7,8-trimethoxy-4-amino-2-(4-substituted piperazin-1-yl)quinazolines are produced by either: (1) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzonitrile with certain 1,4-disubstituted piperazines; or (2) reaction of the appropriate 4,5-dimethoxy substituted or 3,4,5-trimethoxy substituted 2-aminobenzamidine with the same 1,4-disubstituted piperazines. The products are known hypotensive agents.