157947-87-0

Basic information

• Product Name: N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)phenylacetamide
• Synonyms: N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)phenylacetamide
• CAS NO: 157947-87-0
• Molecular Formula: C21H26 N2 O
• Molecular Weight: 322.44
• Mol File: 157947-87-0.mol

Chemical Properties

• Boiling Point: 486.6°Cat760mmHg
• Flash Point: 205.4°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 1.27E-09mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)phenylacetamide(157947-87-0)
• EPA Substance Registry System: N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)phenylacetamide(157947-87-0)

Safety Data

• Hazardous Substances Data: 157947-87-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C21H26N2O/c1-22(21(24)16-18-10-4-2-5-11-18)20(17-23-14-8-9-15-23)19-12-6-3-7-13-19/h2-7,10-13,20H,8-9,14-17H2,1H3

Upstream product

• 103-82-2 phenylacetic acid 
• 116508-51-1 (1S)-N-methyl-1-phenyl-2-(pyrrolidin-1-yl)ethanamine 

Relevant articles and documents

Arylacetamide κ opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity

Some κ opioid receptor agonists of the arylacetamide class, for example, ICI 199441 (1), were found to strongly inhibit the activity of cytochrome P450 2D6 (CYP2D6) (1: CYP2D6 IC50 = 26 nM). Certain analogs bearing a substituted sulfonylamino group, for example, 13, were discovered to have significantly reduced CYP2D6 inhibitory activity (13: CYP2D6 IC50 > 10 μM) while displaying high affinity toward the cloned human κ opioid receptor, good κ/δ and κ/μ selectivity, and potent in vitro and in vivo agonist activity.

Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists

PCT No. PCT/US98/07832 Sec. 371 Date Jun. 30, 1999 Sec. 102(e) Date Jun. 30, 1999 PCT Filed Apr. 17, 1998 PCT Pub. No. WO98/49141 PCT Pub. Date Nov. 5, 1998The novel compounds of formula (I) of the instant invention are selective kappa opioid agonists use

Isothiocyanate-Substituted κ-Selective Opioid Receptor Ligands Derived from N-Methyl-N-phenylacetamide

The synthesis of isothiocyanate-substituted κ-selective opioid ligands derived from N-methyl-N-ethyl>phenylacetamide (8) and their effects in radioligand displacement assays are reported.Ligands 3-5 with the S-absolu