- Method for preparing amide compounds by using supported metal oxide catalytic material
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The invention relates to a catalyst for preparing amide compounds, and aims to provide a method for preparing amide compounds by using a supported metal oxide catalytic material. The method comprisesthe following steps: uniformly mixing a solvent, water, an organic nitrile compound and the catalytic material; performing a reaction at 50-180 DEG C for 0.5-48 h; and hydrating and converting the organic nitrile compound into the corresponding amide compounds through the catalytic hydration effect of the catalyst in the reaction process. Adsorption and activation of the catalytic material to water molecules can be effectively regulated by regulating metal components loaded on the catalytic material and a catalytic material carrier, so that important amide compounds in chemical and agricultural processes are efficiently prepared. The provided method for preparing the amide compounds is effect, and has the advantages of high atom utilization rate in the reaction process, low reaction temperature, no additional reaction assistant in the synthesis process, no generation of toxic or harmful byproducts after the reaction, and green and environment-friendly synthesis process.
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Paragraph 0156; 0157
(2020/06/05)
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- Preparation method and equipment of 4-trifluoromethyl-nicotinic acid
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The invention discloses a preparation method of 4-trifluoromethyl-nicotinic acid. The preparation method comprises the following steps: taking cyanoacetamide, ethyl trifluoroacetoacetate and strong alkali as raw materials; firstly, preparing 2,6-dihydroxyl-3-cyano-4-tirfluoromethylpyridine; after carrying out chlorination through phosphorus oxychloride to obtain 2,6-dichloro-3-cyano-4-tirfluoromethylpyridine; then adding sulfuric acid to convert cyano into amino; and carrying out catalytic hydrogenation and hydrolysis to obtain the 4-trifluoromethyl-nicotinic acid. The preparation method has the advantages of high conversion rate and reduction of the cyano; the cyano is used as a strong electron suction group and has a carbon-nitrogen triple bond with relatively strong polarity; after thecyano is eliminated, the reduction rate can be remarkably reduced and the yield is improved; and the preparation method is worthy of being greatly popularized.
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- Synthesis method of 2,6-dichloro-4-trifluoromethyl nicotinamide
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The invention discloses a synthesis method of 2,6-dichloro-4-trifluoromethyl nicotinamide. Through the synthesis method, 2,6-dihydroxyl-3-cyano-4-trifluoromethylpyridine, phosphoric oxychloride, 2,6-dichloro-3-cyano-4-tirfluoromethylpyridine, concentrated
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Paragraph 0008
(2018/10/19)
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- Nicotinamide compound as well as preparation method and application thereof
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The invention provides a nicotinamide compound of which the structural formula is as shown in the specification, in the formula, R1 and R2 are one of F, Cl, Br, I, methyl, tertiary butyl, trifluoromethyl, halogenated alkyl, hydroxyl, nitryl, amino, cyan,
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- Amide compounds and their salts and pesticidal compositions containing them
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The present invention relates to an amide compound and its salt, process for its production and a pesticidal composition containing it. The amide compound of the formula (I) or its salt: STR1 wherein the radicals are defined in the claims.
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