Synthesis of a potential antiviral compound: 5-Bromoethynyl-2'- deoxyuridine
5-Bromoethynyluracil and its deoxyriboside can be prepared in good yields starting from dibromovinyluracil, which is accesible by literature methods. 5-Bromoethynyl-deoxyuridine is less effective against HSV-1 than E- (bromovinyl)-deoxyuridine but, similar to BVDU, seems to exhibit a certain selectivity toward HSV-1. Molecular calculations prove the spatial similarity of both compounds.
Eger,Jalalian,Schmidt
p. 8371 - 8380
(2007/10/02)
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