Rapid conversion of unprotected galactose analogs to their UDP-derivatives for use in the chemoenzymatic synthesis of unnatural oligosaccharides
The rapid conversion of D-galactose, its 2-deoxy, 3-deoxy, 4-deoxy and 6-deoxy derivatives and L-arabinose to their UDP-derivatives (2-7) is described. The procedure involves the in situ preparation of the per-O-trimethylsilylated glycopyranosyl iodides and their direct reaction with UDP. All six sugar nucleotides were active as substrates for β(1→4)-galactosyltransferase and were used to enzymatically prepare N-acetyllactosamine (8) and five of its analogs (9-13).
Uchiyama, Taketo,Hindsgaul, Ole
p. 1181 - 1190
(2007/10/03)
Further studies on the mechanism of action of UDP apiose/UDP xylose synthase from cell cultures of parsley
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Baron,Grisebach
p. 153 - 159
(2007/10/09)
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