158465-13-5

Basic information

• Product Name: 2-Benzothiazolamine,5,7-dichloro-(9CI)
• Synonyms: 2-Benzothiazolamine,5,7-dichloro-(9CI);5,7-Dichloro-2-benzothiazolamine;2-BenzothiazolaMine, 5,7-dichloro-;5,7-Dichloro-benzothiazol-2-ylamine
• CAS NO: 158465-13-5
• Molecular Formula: C₇H₄Cl₂N₂S
• Molecular Weight: 219.095
• EINECS: 200-258-5
• Product Categories: BENZOTHIAZOLE
• Mol File: 158465-13-5.mol

Chemical Properties

• Boiling Point: 376.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.654
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.17±0.30(Predicted)
• CAS DataBase Reference: 2-Benzothiazolamine,5,7-dichloro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzothiazolamine,5,7-dichloro-(9CI)(158465-13-5)
• EPA Substance Registry System: 2-Benzothiazolamine,5,7-dichloro-(9CI)(158465-13-5)

Safety Data

• Hazardous Substances Data: 158465-13-5(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Upstream product

• 626-43-7 3,5-Dichloroaniline 
• 13330-18-2 3,5-dichloroaniline hydrochloride 
• 107707-33-5 N-[3,5-dichlorophenyl]thiourea 

Downstream Products

• 898747-71-2 2-bromo-5,7-dichlorobenzo[d]thiazole 
• 227012-70-6 Bis(2-amino-4,6-dichlorophenyl)disulfide 
• 227012-75-1 2-(3-bromo-benzyl)-6,8-dichloro-4H-benzo[1,4]thiazin-3-one 
• 227012-74-0 2-benzyl-6,8-dichloro-4H-benzo[1,4]thiazin-3-one 
• 131105-96-9 2-Amino-4,6-dichlorothiophenol 

Relevant articles and documents

AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

Quinazolinone and isoquinolinone derivative

The present invention relates to quinazolinone and isoquinolinone derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.

Synthesis of 2-substituted-6,8-dichloro-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-1,1-dioxides and -1-oxides as glycine-NMDA receptor antagonists

A number of 2-substituted-3,4-dihydro-3-oxo-6,8-dichloro-2H-1,4-benzothiazine-1,1-dioxides (1-2a-b) and -1-oxides (3-4a-b) bioisosters of RPR 104632 in which the 3-carboxylic group was replaced by a carbonyl group were synthesized. Comparative in vitro pharmacological studies on this series of RPR 104632 analogs were performed using receptor binding assays. None of these compounds showed detectable binding affinity for the glycine-NMDA receptor.