- Practical total syntheses of acromelic acids A and B
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Practical total syntheses of acromelic acids A (1) and B (2), which have potent neuro-excitatory activity, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), respectively, from 2,6-dichloropyridine (8). Regioselective transformation of symmetric 8 provided nitroalkenes 15 and 16. The pyrrolidine ring was efficiently constructed by Ni-catalyzed asymmetric conjugate addition followed by intramolecular reductive amination.
- Ouchi, Hitoshi,Asahina, Aya,Asakawa, Tomohiro,Inai, Makoto,Hamashima, Yoshitaka,Kan, Toshiyuki
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p. 1980 - 1983
(2014/05/06)
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