- Convenient synthesis of C-aza-2,3-dideoxynucleosides
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l-Aryl-l,2,3,4-tetradeoxy-l,4-imino-D-pentitols 5 and 9f are easily synthesized from TV-Boc-L-pyroglutamate 1 via a successive procedure involving regioselective ring-opening, recyclization with dehydration, stereoselective reduction, and reduction of the
- Momotake, Atsuya,Togo, Hideo,Yokoyama, Masataka
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p. 1193 - 1200
(2007/10/03)
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- Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action
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Mercaptoacyl dipeptides, containing a glycine linked to a C-terminal 5- phenylproline, have been synthesized in order to obtain new highly efficient dual inhibitors of the two zinc metallopeptidases, neutral endopeptidase (NEP) and angiotensin-converting
- Fournie-Zaluski, Marie-Claude,Coric, Pascale,Thery, Vincent,Gonzalez, Walter,Meudal, Hervé,Turcaud, Serge,Michel, Jean-Baptiste,Roques, Bernard P.
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p. 2594 - 2608
(2007/10/03)
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- Stereoselective Addition of Grignard-Derived Organocopper Reagents to N-Acyliminium Ions: Synthesis of Enantiopure 5- and 4,5-Substituted Prolinates
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Alkylation of nonracemic N-acyliminium ions derived from proline and 4-substituted prolines has been extended to different types of Grignard-derived organocopper reagents.The reaction proceeds with high yield and stereoselectivity to yield 5-mono- and 4,5-disubstituted prolinates.The stereochemistry is controlled by the formation of a RCu-? complex intermediate between the N-acyliminium ion, the carbonyl group of the ester, and the copper species.
- Collado, Ivan,Ezquerra, Jesus,Pedregal, Concepcion
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p. 5011 - 5015
(2007/10/03)
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