Nucleosides. Part LV. Efficient synthesis of arabinoguanosine building blocks
From guanosine (1) as starting molecule, protected arabinoguanosine derivatives such as phosphoramidite precursors and arabinoguanosine (18) itself were prepared in high yields. Inversion of the configuration at C(2') was achieved by introduction of the (trifluoromethyl)sulfonyl residue and subsequent displacement by nucleophiles like acetate, bromide, and azide. The guanine moiety was protected at the amide function by the 2-(4-nitrophenyl)ethyl (npe) group on O6 and at the NH2 function by the 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) group.
An Improved Synthesis of 2'-O-(13C) Methylguanosine
Using methyl iodide as a source of 13C label, an efficient and regioselective synthesis of 2'-O-(13C)methylguanosine has been elaborated.The synthesis of the fully protected 2'-O-(13C)methylguanosine-3'-O-phosphoramidite (9), the building unit for the oli
Sochacka, Elzbieta,Starosta, Agnieszka,Malkiewicz, Andrzej
p. S59 - S62
(2007/10/03)
More Articles about upstream products of 158604-45-6