15862-61-0Relevant articles and documents
Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
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Page 121, (2010/02/09)
The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
Design and synthesis of the potent, orally available, brain-penetrable arylpyrazole class of neuropeptide Y5 receptor antagonists
Sato, Nagaaki,Takahashi, Toshiyuki,Shibata, Takunobu,Haga, Yuji,Sakuraba, Aya,Hirose, Masaaki,Sato, Miki,Nonoshita, Katsumasa,Koike, Yuko,Kitazawa, Hidefumi,Fujino, Naoko,Ishii, Yasuyuki,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro
, p. 666 - 669 (2007/10/03)
Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y (NPY) Y5 receptor antagonists. Compound (-)-7, which features a novel chiral 2,3-dihydro-1H-cyclopenta [a] naphthalene moiety, showed good binding affinity and antagonistic ac