158688-63-2

Basic information

• Product Name: 4-AMino-1-phenyl-1H-iMidazole HCl
• Synonyms: 4-AMino-1-phenyl-1H-iMidazole HCl;1-phenyl-1H-iMidazol-4-aMine;1-phenyl-1H-iMidazol-4-aMine hydrochloride
• CAS NO: 158688-63-2
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 195.6488
• Mol File: 158688-63-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-AMino-1-phenyl-1H-iMidazole HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMino-1-phenyl-1H-iMidazole HCl(158688-63-2)
• EPA Substance Registry System: 4-AMino-1-phenyl-1H-iMidazole HCl(158688-63-2)

Safety Data

• Hazardous Substances Data: 158688-63-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
4-Amino-1-phenyl-1H-imidazole HCl is used as a research compound for its potential antiviral and antifungal properties, making it a valuable asset in the development of new medications targeting these areas.
Used in the Synthesis of Other Pharmaceuticals:
In the pharmaceutical industry, 4-Amino-1-phenyl-1H-imidazole HCl serves as a key intermediate in the synthesis of various pharmaceuticals, contributing to the creation of novel therapeutic agents.
Used in Antiviral Applications:
4-Amino-1-phenyl-1H-imidazole HCl is used as an antiviral agent, potentially inhibiting the replication and spread of viruses, thereby offering a means to combat viral infections.
Used in Antifungal Applications:
Similarly, in antifungal applications, 4-Amino-1-phenyl-1H-imidazole HCl is utilized to target and inhibit the growth of fungi, providing a potential treatment for fungal infections.

Upstream product

• 41384-83-2 1-phenyl-4-nitro-1H-imidazole 
• 98-80-6 phenylboronic acid 

Downstream Products

• 83325-36-4 N-(1-phenyl-1H-imidazol-4-yl)-acetamide 
• 90946-05-7 N-(1-phenyl-1H-imidazol-4-yl)-formamide 
• 1178533-25-9 1-phenyl-5-(2-thienyl)-7-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine 
• 1178533-24-8 5-methyl-1-phenyl-7-(trifluoromethyl)-1H-imidazo[4,5-b]pyridine 
• 268538-46-1 phenyl (1-phenyl-1H-imidazol-4-yl)carbamate 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

CYANO-SUBSTITUTED HETEROCYCLES WITH ACTIVITY AS INHIBITORS OF USP30

The present invention relates to cyano-substituted-heterocycles of Formula (I) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction. (Formula (I))

CYANOPYRROLIDINE DERVIVATIVES AS INHIBITORS FOR DUBS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1 and ubiquitin C-terminal hydrolase 30 or Ubiquitin Specific Peptidase 30 (USP30). The invention further relates to the use of DUB inhibitors in the treatment of cancer. Compounds of the invention include compounds having the formula (I): pharmaceutically acceptable salt thereof, wherein R1a, R1b, R1c, R1d, R1e, R1f and A are as defined herein.

Facile synthesis of fluorinated 1-desazapurines

A preparative approach towards 1-desazapurines, starting from 4(5)-aminoimidazoles and polyfluoroalkyl-containing 1,3-CCC-biselectrophiles was developed. As a result, a set of fluorinated 1-desazapurines was synthesized. Additionally, a synthetic route to 1-desazapurines bearing a sugar-mimicking group is proposed. Georg Thieme Verlag Stuttgart.

Reduction of 1-Aryl-4-Nitroimidazoles to 4-Amino-1-Arylimidazoles

1-aryl-4-nitroimidazoles on reduction with hydrogen in methanol at 25 degC, in the presence of Raney nickel, yield the unstable 4-amino-1-aryl-imidazoles which can be acylated e.g. with pentafluorophenyl formate, formic acid in the presence of dicyclohexy