Discovery of novel imidazo[4,5- b ]pyridines as potent and selective inhibitors of phosphodiesterase 10A (PDE10A)
We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioavailab
Hu, Essa,Andrews, Kristin,Chmait, Samer,Zhao, Xiaoning,Davis, Carl,Miller, Silke,Hill Della Puppa, Geraldine,Dovlatyan, Mary,Chen, Hang,Lester-Zeiner, Dianna,Able, Jessica,Biorn, Christopher,Ma, Ji,Shi, Jianxia,Treanor, James,Allen, Jennifer R.
p. 700 - 705
(2014/07/07)
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