A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides
A new tandem decyanation/cyanation reaction of α-iminonitriles has been developed. A variety of cyano-substituted aryl amides and heteroaryl amides are synthesized in good yields. Both electron-rich and electron-deficient groups are compatible with the standard conditions. This reaction features a nonmetallic cyano source, tandem decyanation and cyanation reaction, waste utilization of the HCN from the hydrolysis of α-iminonitriles, formation of two important functional groups in one-step operation, etc.
Chen, Zhengwang,Liang, Pei,Liu, Botao,Luo, Haiqing,Zheng, Jing,Wen, Xiaowei,Liu, Tanggao,Ye, Min
p. 8481 - 8485
(2018/11/27)
Highly efficient synthesis of fused bicyclic 2,3-diaryl-pyrimidin-4(3H)-ones via Lewis acid assisted cyclization reaction
An expedient one-pot synthesis of fused bicyclic 2,3-diaryl-pyrimidin-4(3H)-ones from three readily available components is described. The key step is a Lewis acid assisted cyclization reaction.
Yang, Kunyong,He, Xiaohui,Choi, Ha-soon,Wang, Zhicheng,Woodmansee, David H.,Liu, Hong
p. 1725 - 1728
(2008/09/17)
The Effect of Electron Withdrawing Groups in the Amide and Bromo Components on the Yield of the "Goldberg Reaction"
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Dharmasena, Priyanthi M.,Oliveira-Campos, Ana-M. F.,Raposo, M. Manuela M.,Shannon, Patrick V. R.
p. 1601 - 1611
(2007/10/02)
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