Efficient assembly of threaded molecular machines for sequence-specific synthesis
We report on an improved strategy for the preparation of artificial molecular machines that can pick up and assemble reactive groups in sequence by traveling along a track. In the new approach a preformed rotaxane synthon is attached to the end of an otherwise fully formed strand of building blocks. This rotaxane-capping protocol is significantly more efficient than the final-step-threading method employed previously and enables the synthesis of threaded molecular machines that operate on extended oligomer, and potentially polymer, tracks. The methodology is exemplified through the preparation of a machine that adds four amino acid building blocks from a strand in sequence, featuring up to 20-membered ring native chemical ligation transition states.
De Bo, Guillaume,Kuschel, Sonja,Leigh, David A.,Lewandowski, Bartosz,Papmeyer, Marcus,Ward, John W.
p. 5811 - 5814
(2014/05/06)
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