- 6H-THIENO[2,3-E][1,2,4]TRIAZOLO[3,4-C][1,2,4]TRIAZEPINE DERIVATIVE
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The 6H-thieno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazepine derivatives or salts thereof of the present invention have BRD4 inhibitory activity, and thus, they are useful as medicaments, in particular, as prophylaxis and/or therapeutic agents for diseases associated with BRD4.
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Paragraph 0457; 0460-0461
(2020/05/07)
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- Novel D-amino acid oxidase (DAAO) inhibitor as well as preparation method and application thereof
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The invention provides a novel D-amino acid oxidase (DAAO) inhibitor as well as a preparation method and application thereof, and in particular discloses 3-hydroxyl-3,4-dihydroquinazoline-2(1H)-one compounds as shown in a formula A, derivatives of the compounds, a preparation method of the compounds and the derivatives of the compounds, and use of the compounds and the derivatives of the compounds as the DAAO inhibitor. The compounds have good functions of easing pain and blocking tolerance to morphine analgesia, thus having the application value of analgesia, treatment for opium drug tolerance and schizophrenia resistance.
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- Bicyclic And Tricyclic Compounds As KAT II Inhibitors
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Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.
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Page/Page column 25-26
(2010/12/31)
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