15938-72-4

Basic information

• Product Name: Coumarin
• Synonyms: 3,3'-(3,4,5-TRIMETHOXYBENZYLIDENE)BIS(4-HYDROXYCOUMARIN)
• CAS NO: 15938-72-4
• Molecular Formula: C₂₈H₂₂O₉
• Molecular Weight: 146.14274
• Mol File: 15938-72-4.mol

Chemical Properties

• Boiling Point: 666.2°Cat760mmHg
• Flash Point: 223.2°C
• Appearance: /
• Density: 1.461g/cm³
• CAS DataBase Reference: Coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: Coumarin(15938-72-4)
• EPA Substance Registry System: Coumarin(15938-72-4)

Safety Data

• Hazardous Substances Data: 15938-72-4(Hazardous Substances Data)

Upstream product

• 22105-09-5 4‐hydroxycoumarin 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 

Downstream Products

• 375359-23-2 7-(3,4,5-trimethoxy-phenyl)-4aH-pyrano[3,2-c:5,6-c']dichromene-6,8-dione 

Relevant articles and documents

Camphor sulfonic acid catalyzed facile and general method for the synthesis of 3,3'-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones), 3,3'-(arylmethylene)bis(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline-3,3-diyl)bis(2-hydroxynaphthalene-1,4-dio

Camphor sulfonic acid catalyzed a straightforward, efficient, and general method has been developed for the synthesis of 3,3'-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones), 3,3'-(arylmethylene)bis(2-hydroxynaphthalene-1,4-diones) and 3,3'-(2-oxoindoline

Unveiling the anti-tubercular properties of biscoumarins, through biological evaluation and docking studies

Background: Biscoumarin scaffolds are known for their promising pharmacological properties. These compounds have not been studied for their activity against tuberculosis strains. Objective: Unveil the antitubercular properties of biscoumarin scaffolds. Me

Thiamine hydrochloride as a recyclable organocatalyst for the synthesis of bis(indolyl)methanes, tris(indolyl)methanes, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarins

Thiamine hydrochloride was identified as an eco-friendly organocatalyst for the synthesis of a broad range of bis(indolyl)methanes in good to excellent yields. Green chemistry matrix calculations showed high atom economy and a small E-factor for the reaction. Moreover, the simple and easy operational protocol using a small amount of thiamine hydrochloride (1 mol%) makes this procedure an alternative approach for this transformation industrially. This protocol was also extended to the synthesis of naturally occurring alkaloids such as tris(indolyl)methane, arundine, vibrindole A, 3,3-di(indol-3-yl)indolin-2-ones and biscoumarin derivatives.

L-Tyrosine loaded nanoparticles: An efficient catalyst for the synthesis of dicoumarols and Hantzsch 1,4-dihydropyridines

Environmentally benign l-tyrosine loaded nanoparticles are fabricated and characterized by PCS, TEM, FT-IR and AFM studies. A novel straightforward green approach was applied for the synthesis of dicoumarols and Hantzsch 1,4-dihydropyridines using this catalyst. The structures and purity of these compounds were confirmed by FT-IR and NMR (1H, 13C and DEPT). The flexible and swelling properties of the polymer coating increase l-tyrosine dispersion and its high catalytic activity in organic reactions. This journal is

Ca(II)-catalyzed, one-pot four component synthesis of functionally embellished benzylpyrazolyl coumarins in water

A facile one-pot, four-component synthesis of biologically important benzylpyrazolyl coumarins in water has been demonstrated using environmentally benign Ca(II) as the catalyst. Participation of aliphatic aldehydes has been described for the first time. Short reaction times, high yields and chromatography free isolation of the products, usage of eco-friendly catalyst and solvent are the key features of this method.

Mohr's salt hexahydrate: A novel, cheap and powerful reagent for green synthesis of biscoumarins on water

Anew and convenient method for the synthesis of biscoumarins based on the condensation of 4-hydroxycoumarin and aromatic aldehydes in the presence of Mohr's salt hexahydrate (ferrous ammonium sulfate hexahydrate) as a novel catalyst on water is developed.

Sulfated titania catalyzed water mediated efficient synthesis of dicoumarols - A green approach

An efficient, mild, and environmental friendly method has been developed for the synthesis of dicoumarols in water over Lewis and Bronsted acid catalyst sulfated titania (TiO2/SO42-). The method involves the condensation of various aromatic and aliphatic aldehydes with 4-hydroxycoumarin. It affords the corresponding product in high yield with short reaction times employing a very low loading of catalyst. The catalyst was reused several times without significant change in activity.

Tetrabutylammonium bromide (TBAB): a neutral and efficient catalyst for the synthesis of biscoumarin and 3,4-dihydropyrano[c]chromene derivatives in water and solvent-free conditions

A simple, efficient and ecofriendly procedure has been developed using tetrabutylammonium bromide as catalyst for the synthesis of biscoumarin and dihydropyrano[c]chromene derivatives in water and solvent-free neat conditions. The present methodology offe

Synthesis, structure, antimicrobial and antioxidant investigations of dicoumarol and related compounds

Different substituted 3,3′-arylidenebis-4-hydroxycoumarins (1-7) and tetrakis-4-hydroxycoumarin derivative 8 are the final products when 4-hydroxycoumarin and aromatic aldehydes containing different groups in ortho, meta or para positions condense in boil

Synthesis, structure, toxicological and pharmacological investigations of 4-hydroxycoumarin derivatives

Twenty 4-hydroxycoumarin derivatives were synthesized. Five of them are described for the first time. The X-ray crystal structure analysis of 3,3′-(2,3,4-trimethoxyphenylmethylene)bis-(4-hydroxy-2H-1-benzopyran-2-one) (7) and 3,3′-(3,5-dimethoxy-4-hydroxy