Total synthesis of monosporascone and dihydromonosporascone
The first total synthesis of monosporascone is presented. The five-step synthesis developed includes a silver acetylide-acid chloride coupling, domino Diels-Alder-retro-Diels-Alder reaction, and an intramolecular Friedel-Crafts acylation, and provides the natural product in 57% yield overall. Selective reduction of monosporascone also afforded the related metabolite dihydromonosporascone. This journal is the Partner Organisations 2014.
Punch, Kathryn A.,Piggott, Matthew J.
p. 2801 - 2810
(2014/05/06)
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