Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines
The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.
Akram, Manjur O.,Das, Avishek,Chakrabarty, Indradweep,Patil, Nitin T.
supporting information
p. 8101 - 8105
(2019/10/11)
Base-catalysed Reaction of p- and o-Nitroanilines with Isocyanates and Isothiocyanates
The reaction of p-nitroaniline with aryl isocyanates (2a-2d) in the presence of potassium carbonate leads to 4-nitrophenylamines (4a-4d).The reaction of p-nitroaniline with n-propyl isocyanate yields 4,4'-dinitrodiphenyl amine (10). o-Nitroaniline reacts with the isocyanates (2a and 2b) to yield 2-nitrodiphenyl amines (11a and 11b).The reaction of p-nitroaniline with phenyl isothiocyanate yields the guanidine (12) besides 4-nitrodiphenylamine (4a) and N,N'-diphenylthiourea.
Viswanathan, N.,Sidhaye, A. R.
p. 611 - 613
(2007/10/02)
Process for the preparation of nitro diphenyl amine derivatives
A process for the preparation of nitro-diphenyl amines is disclosed by decarboxylation of a urethane in the presence of a base at an elevated temperature using tetramethylene sulphone as reaction medium is disclosed. The urethane can be one formed by the reaction of a nitrophenol with an aromatic isocyanate.
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(2008/06/13)
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