Aqueous hetero Diels-Alder reactions: The carbonyl case
Commercially available aqueous solution of glyoxylic acid, pyruvaldehyde and glyoxal were shown to react with cyclic or non-cyclic dienes to give the corresponding cycloadducts and/or α-hydroxy γ-lactones. Activated ketone (Pyruvic acid) was shown to react as well in the same conditions.