- Co-Catalyzed Intramolecular S-N Bond Formation in Water for 1,2-Benzisothiazol-3(2H)-ones and 1,2,4-Thiadiazoles Synthesis
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An efficient and versatile Co-catalyzed intramolecular S-N bond formation in water to synthesize 1,2-benzisothiazol-3(2H)-one and 1,2,4-thiadiazoles derivatives in good to excellent yields was developed. The transformation showed great tolerance with a broad range of substituents. The mother liquor was able to be recycled 6 times with minor loss in product yield.
- Yang, Liting,Song, Lijuan,Tang, Shanyu,Li, Longjia,Li, Heng,Yuan, Bingxin,Yang, Guanyu
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p. 1281 - 1285
(2019/01/14)
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- Synthesis of 5-Amino and 3,5-Diamino Substituted 1,2,4-Thiadiazoles by I2-Mediated Oxidative N-S Bond Formation
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An oxidative N-S bond formation reaction has been established for 1,2,4-thiadiazole synthesis employing molecular iodine as the sole oxidant. The features of the present reaction include no use of transition metals, mild reaction conditions, simple operat
- Wang, Bingnan,Meng, Yinggao,Zhou, Yiming,Ren, Linning,Wu, Jie,Yu, Wenquan,Chang, Junbiao
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p. 5898 - 5903
(2017/06/07)
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- NOVEL FLAVONE BASED EGFR INHIBITORS AND PROCESS FOR PREPARATION THEREOF
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The present invention discloses a novel EGFR inhibitor compound of formula (1), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (1). wherein, R is selected from hydrogen, alkyl, nitro, halogens such as chlorine, bromine, fluorine and iodine; Rl= hydrogen, alkyl, alkoxy, aryl, nitro, halogens such as chlorine, bromine, fluorine and iodine, trifluoromethyl, thioalkyl, trifluromethoxy, trialkylsilyl.
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Page/Page column 14
(2016/09/22)
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- NOVEL BENZIMIDAZOLE BASED EGFR INHIBITORS
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The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in mammals by administering the compounds of formula (I). Wherein, R= -H, 3-CH3, 4-NO2, 4-Cl, 2-CH3, 4-CH3, 4-Br, 4-F R1= -H, -4-OCH3, -4-NO2,-2-NO2, -4-Cl, -2,4,6-CH3, -4-CH3, -2-F,4-Br, -4-CF3, -4-S-CH3, -4-Cl,-3-CF3, -3-S-CH3, -3,5-CF3, -2-S-CH3, -3-CF3,-4-OCF3, -Si-(CH3)3, -Si-(C2H5)3, (CH3)2-Si- C2H5.
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- Studies in the antimicrobial activities of 1-substituted-3-formamidinothio- carbamides and 1,3-bis-(substitutedthioamido)guanidines
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The present research work has been undertaken in the synthesis of nitrogen, nitrogen and sulphur containing heteroacycles and heterocycles and to investigate their applications in medicinal, agricultural, industrial, pharmacological and biochemical facult
- Waghmare,Tayade,Shelke,Patil
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p. 819 - 821
(2007/10/03)
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- Synthesis and antimicrobial activity of 1,3,5-thiadiazines and their isomerism into 1,3,5-triazines
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A series of 2,6-diphenylimino-4-(substituted)-benzylidene amino-1,3,5-thiadiazines 4a-g have been obtained by the basification of their hydrochlorides 3a-g, which are prepared by interaction of N-phenyl isocyanodichloride and 1-(substituted)-benzylidene amidino-3-phenyl thiocarbamides 2a-g. The latter have been synthesized by the condensation of 1-amidino-3-phenyl thiocarbamide 1 and different aliphatic and aromatic aldehydes. Compounds 4a-g on acylation afford monoacetyl derivatives 5a-g, on reaction with sodium nitrite in acidic medium afforded mononitroso derivatives 6a-g, and on boiling with 5% aqueous ethanolic (1:1) sodium hydroxide solution isomerize into corresponding 1-phenyl-2-phenylimino-4-(substituted)-benzylidene amino-6-thio-1,3,5-triazines 7a-g. The title compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.
- Deohate, Pradip P.,Berad
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p. 638 - 642
(2007/10/03)
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- Conversion of alkylamines to thiocarbamoylguanidines
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N-Alkyl-, N,N-dialkyl- or N-unsubstituted-N'-(arylthiocarbamoyl)guanidines are prepared in very good yield from amines and 1-(N-arylthiocarbamoyl)amidino3,5 -dimethylpyrazoles.
- Francis,Deepa,Sreekala,Rajasekharan
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p. 3463 - 3470
(2007/10/03)
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