- INDUCTION OF CELL ARREST IN G2: STRUCTURAL SPECIFICITY OF TRIGONELLINE
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Synthetic analogues of N-methyl nicotinic acid, trigonelline, were prepared to test the structural features necessary for the induction of cellular arrest in G2 in Pisum sativum.Analogues that (1) were regioisomers of trigonelline, (2) possessed different 1,3-substituents, ad (3) contained additional substituents on the pyridine ring were tested for their ability to induce cell arrest in G2 and to anatogize trigonelline induced arrest in G2.Only N-methyl-3-quinoline-carboxic acid and 1-methyl nicotinamide induced cell arrest in G2, and 1-methyl-4-pyridine carboxylic acid and 1-methyl-2-pyridine carboxylic acid were effective trigonelline antagonists.These data further support a specific role for trigonelline in the induction of cell arrest in G2.Key words: Pisum sativum; Leguminosae; pea; trigonelline; structural specificity; structural analogues; cell arrest; G2.
- Lynn, David G.,Lewis, David H.,Tramontano, William A.,Evans, Lance S.
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p. 1225 - 1228
(2007/10/02)
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- COVALENT ADDUCTS FROM 1,3-DISUBSTITUTED PYRIDINIUM SALTS AND PIPERIDINE
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Covalent adducts 3a-f have been isolated from the reaction between piperidine and pyridinium salts 1a-f. 3a-f are stable both in the solid state and in apolar solvents, whereas their fast dissociation back to piperidine and pyridinium ions occurs in aqueous solution.The latter, in the alkaline environment produced by the amine, yields the correspondent pseudobases, which are key intermediates of the subsequent reactions.For instance, the pseudobases from 1a,b can undergo either a ring-opening reaction or a redox process with the corresponding pyridinium cations.
- Moracci, F. Micheletti,Rienzo, B. Di,Tortorella, S.,Liberatore, F.
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p. 785 - 789
(2007/10/02)
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