Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones
The nickel/(S)-Binapine complex was found to be an efficient catalyst for asymmetric hydrogenation of β-acetylamino vinylsulfones to afford chiral β-Amido sulfones with excellent yields and enantioselectivities (up to 95% yields and >99% ee). This protocol has good compatibility with a series of substituted (Z)-β-acetylamino vinylsulfones or Z/E isomeric mixtures. A gram-scale reaction has also been achieved in the presence of a 0.2 mol % catalyst loading.
Rhodium-catalyzed asymmetric hydrogenation of β-acetylamino acrylosulfones: A practical approach to chiral β-amido sulfones
The efficient and highly enantioselective catalytic asymmetric hydrogenation of β-acetylamino acrylosulfone has been achieved by employing Rhodium-TangPhos as catalyst. A series of β-amido sulfone products are obtained with excellent yields and good enantioselectivities.
Jiang, Jun,Wang, Yan,Zhang, Xumu
p. 1570 - 1573
(2014/05/20)
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