15996-76-6

Basic information

• Product Name: 4-(Aminomethyl)benzonitrile hydrochloride
• Synonyms: 4-CyanobenzylaMine HCl Salt;4-(Aminomethyl)benzonitrile hydrochloride 97%;4-(Aminomethyl)benzonitrile hydrochloride, >=99%;α-Amino-p-tolunitrile Hydrochloride;4-CNBAM X HCL;4-CYANOBENZYLAMINE HYDROCHLORIDE;4-(AMINOMETHYL)BENZONITRILE HCL;4-(AMINOMETHYL)BENZONITRILE HYDROCHLORIDE
• CAS NO: 15996-76-6
• Molecular Formula: C₈H₈N₂*ClH
• Molecular Weight: 168.62
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Nitrile
• Mol File: 15996-76-6.mol

Chemical Properties

• Melting Point: 274-279 °C(lit.)
• Boiling Point: 275.4 °C at 760 mmHg
• Flash Point: 120.4 °C
• Appearance: White solid
• Vapor Pressure: 0.0051mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Water Solubility: almost transparency
• CAS DataBase Reference: 4-(Aminomethyl)benzonitrile hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Aminomethyl)benzonitrile hydrochloride(15996-76-6)
• EPA Substance Registry System: 4-(Aminomethyl)benzonitrile hydrochloride(15996-76-6)

Safety Data

• Statements: 20/21/22-36/37/38-22
• Safety Statements: 22-24/25-36/37-26
• WGK Germany: 3
• Hazardous Substances Data: 15996-76-6(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
4-(Aminomethyl)benzonitrile hydrochloride is used as a synthetic intermediate for the production of fluorescent-labeled bisbenzamidine, which serves as a biochemical tool in biomedical studies. This application aids in the visualization and analysis of biological processes at the molecular level.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 4-(Aminomethyl)benzonitrile hydrochloride is used as a key component in the synthesis of 3-(p-benzylamino)-1,2,4,5-tetrazine. 4-(Aminomethyl)benzonitrile hydrochloride is utilized in the modification of alginate hydrogels, which are employed in cell engineering applications. The modified hydrogels can be used for various purposes, such as tissue engineering, drug delivery, and cell culture.
Used in Cell Engineering Applications:
4-(Aminomethyl)benzonitrile hydrochloride plays a role in the development of modified alginate hydrogels, which are essential in cell engineering. These hydrogels provide a supportive and controlled environment for cell growth and differentiation, making them valuable in the fields of regenerative medicine and tissue engineering.

InChI:InChI=1/C8H8N2.ClH/c9-5-7-1-2-8(6-10)4-3-7;/h1-4H,5,9H2;1H

Synthetic route

4-aminobenzyl cyanide (10406-25-4) → 4-cyanobenzylamine hydrochloride (15996-76-6)

Conditions	Yield
With hydrogenchloride In ethyl acetate	99%
With hydrogenchloride In water	75%

Upstream product

• 15996-74-4 4-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzonitrile 
• 17201-43-3 4-cyanobenzyl bromide 
• 10406-25-4 4-aminobenzyl cyanide 
• 143090-18-0 tert-butyl N-(4-cyanophenyl)carbamate 
• 172348-74-2 tert-butyl ((tert-butoxycarbonyl)(4-cyanobenzyl)amino)-methanoate 
• 623-26-7 terephthalonitrile 
• 3034-34-2 4-cyanobenzamide 

Downstream Products

• 143426-60-2 4-(1H-pyrrol-1-ylmethyl)benzonitrile 
• 1026961-32-9 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 4-cyano-benzylamide 
• 451455-56-4 C₂₈H₂₉N₅O₄S 
• 1026272-69-4 {(R)-1-[(S)-2-(4-Cyano-benzylcarbamoyl)-pyrrolidine-1-carbonyl]-2,2-diphenyl-ethylamino}-acetic acid tert-butyl ester 
• 1027617-10-2 4-carbamoylmethyl-5-(4-chlorophenyl)-1-(2-chlorophenyl)-1H-pyrazole-3-carboxylic acid 4-cyanobenzylamide 
• 1206635-54-2 (R)-N-4-(cyano)benzyl 2-(benzyloxycarbonyl)amino-3-hydroxypropionamide 

Relevant articles and documents

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