160133-33-5

Basic information

• Product Name: 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL
• Synonyms: 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL;4,4-Piperidinediethanol, 1-(phenylMethyl)-
• CAS NO: 160133-33-5
• Molecular Formula: C₁₆H₂₅NO₂
• Molecular Weight: 263.38
• Mol File: 160133-33-5.mol

Chemical Properties

• Appearance: /
• Density: 1.077
• CAS DataBase Reference: 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL(160133-33-5)
• EPA Substance Registry System: 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL(160133-33-5)

Safety Data

• Hazardous Substances Data: 160133-33-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,2''-(1-Benzylpiperidine-4,4-diyl)diethanol is used as a chemical intermediate for the synthesis of various drugs, leveraging its benzylpiperidine structure to contribute to the development of new medicinal compounds. Its role in drug synthesis is crucial, as it can influence the pharmacological properties and therapeutic effects of the final drug products.
Used in Research and Development:
In the field of scientific research, 2,2''-(1-Benzylpiperidine-4,4-diyl)diethanol serves as a valuable compound for studying the effects of benzene ring substitutions on molecular properties and potential applications. Researchers utilize 2,2''-(1-BENZYLPIPERIDINE-4,4-DIYL)DIETHANOL to explore its reactivity, stability, and interactions with other molecules, which can lead to the discovery of new chemical reactions and applications in various industries.
Used in Chemical Synthesis:
2,2''-(1-Benzylpiperidine-4,4-diyl)diethanol is employed as a key component in the synthesis of complex organic molecules, where its unique structure can be used to create novel compounds with specific properties. Its versatility in chemical reactions makes it a valuable asset in the development of new materials and products across different sectors, such as materials science, electronics, and environmental science.

Upstream product

• 160133-32-4 ethyl 2-[1-benzyl-4-(2-ethoxy-2-oxoethyl)-4-piperidyl]acetate 

Downstream Products

• 518284-85-0 2-[1-benzyl-4-[2-(tert-butyldiphenylsiloxy)ethyl]piperidin-4-yl]ethanol 
• 160133-34-6 1-Benzyl-4,4-bis-(2-chloroethyl)-piperidinehydrochloride 
• 170229-04-6 1-t-Butoxycarbonylpiperidine-4,4-diethanol 
• 873924-08-4 9-oxo-3-azaspiro[5.5]undecane-3-carboxylic acid tert-butyl ester 
• 1225437-12-6 9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane 
• 1225437-09-1 3-azaspiro[5.5]undecan-9-one hydrochloride 
• 1225437-01-3 tert-Butyl 9-(azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225437-11-5 tert-Butyl 9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225437-13-7 tert-Butyl 9-(3-fluorophenyl)-9-(pyrrolidin-1-yl)-3-azaspiro[5.5]undecane-3-carboxylate 
• 1225436-55-4 1-(9-(azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone 
• 1225436-57-6 1-[3-(3-fluorophenyl)-3-pyrrolidin-1-yl-9-azaspiro[5.5]undecan-9-yl]-2-[1-[[3-(trifluoromethyl)phenyl]sulfonyl]-piperidin-2-yl]-ethanone 
• 1225436-56-5 1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone 

Relevant articles and documents

Substituted Spiroamine Compounds

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME,PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N-R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like.The 4-(2-furoyl) aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

METHOD FOR TREATING MENIERE'S DISEASE

A method for the treatment of Meniere's disease comprising the administration of a medicament which modulates the IKs channel of the ear and thereby reducing endolymph production.

Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

The invention relates to cyclic urea derivatives of general formula I STR1 wherein Ra, Rb, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.

Antiarrhythmic benzodiazepines

Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formulae: STR1

METHODS OF TREATING CARDIAC ARRHYTHMIA

Benzodiazepine analogs have been found to be useful in treating cardiac abnormalities.