- Exploiting novel rotors with auxochromic dynamic motors for monitoring lysosomal viscosity
-
Organelles like lysosomes usually exhibit dynamic changes of locations, morphologies, and components, which could be reflected by the local viscosity. For monitoring lysosomal viscosity, a novel rotor P7-B was introduced with an improved auxochromic dynam
- Xu, Jian-Fei,Gu, Jin,Qi, Ya-Lin,Zhang, Meng,Chen, Jian,Li, Dong-Dong,Yang, Yu-Shun,Lv, Peng-Cheng,Zhu, Hai-Liang
-
-
Read Online
- Direct C-H Arylation and Alkylation of Electron-Deficient Heteroaromatic Compounds with Organozinc Reagents
-
A direct and convenient method for the C-H arylation and alkylation of electron-deficient N-heteroarenes with readily available organozinc reagents has been developed. This transformation could be readily performed in the absence of a transition-metal catalyst and external oxidants, affording a wide range of substituted heteroarenes with good functional group tolerance in good to excellent yields. The developed simple protocol is scalable to the gram level and suitable for late-stage modification of bioactive molecules and drugs.
- Peng, Zhihua,Yu, Chuanman,Wang, Yilei,Wei, Dongyue,Jiang, Cuiyu
-
p. 3678 - 3688
(2021/11/16)
-
- NiH-Catalyzed Hydroamination/Cyclization Cascade: Rapid Access to Quinolines
-
Despite the significant success of metal-H-catalyzed hydroamination methodologies, considerable limitations still exist in the selective hydroamination of alkynes, especially for terminal alkynes. Herein, we develop a highly efficient NiH catalytic system that activates readily available alkynes for a cascade hydroamination/cyclization reaction with anthranils. This mild, operationally simple protocol is amenable to a wide array of alkynes including terminal and internal, aryl and alkyl, electron-deficient and electron-rich ones, delivering structurally diverse quinolines in useful to excellent yields (>80 examples, up to 93% yield). The utility of this procedure is exhibited in the late-stage functionalization of several natural products and in the concise synthesis of an antitumor molecule graveolinine and a triplex DNA intercalator. Preliminary mechanistic experiments suggest an alkenylnickel-mediated alkyne hydroamination and an intramolecular cyclization/aromatization of putative enamine intermediates.
- Chen, Qian,Gao, Yang,Hu, Xiao-Qiang,Huo, Yanping,Li, Xianwei,Yang, Simin
-
p. 7772 - 7779
(2021/06/30)
-
- Synthesis of novel fluorescent parent nucleus containing quinoline ring
-
The invention discloses synthesis of a novel fluorescent parent nucleus containing a quinoline ring. The novel fluorescent parent nucleus has a general structural formula as described in the specification. The invention discloses a synthetic method for the novel fluorescent parent nucleus containing the quinoline ring and application of the novel fluorescent parent nucleus to designing of a fluorescent probe.
- -
-
Paragraph 0025
(2017/12/30)
-
- N, C-CHELATE FOUR-COORDINATE ORGANOBORONS WITH FULL COLOURTUNABILITY
-
The present invention relates to novel full-color tunable light emitter based on N, C-chelate four-coordinate organoborons having excellent Quantum yield, stokes shift and solvate chromism of Formula (I).
- -
-
Page/Page column 17
(2017/04/04)
-
- ONO pincer type Pd(II) complexes: Synthesis, crystal structure and catalytic activity towards C-2 arylation of quinoline scaffolds
-
Four new palladium(II) complexes featuring ONO pincer type hydrazone ligands were synthesized and characterized by spectroscopic and single-crystal XRD analysis. These complexes showed excellent catalytic activity towards the Suzuki-Miyaura cross coupling reaction of 2-chloroquinoline derivatives with various aryl boronic acids. The main advantages over previous methodologies include low catalyst loading, less problematic reaction media (H2O-DMF (80:20%)) and a lower reaction temperature of 60 °C for optimal performance.
- Arumugam, Vignesh,Kaminsky, Werner,Nallasamy, Dharmaraj
-
p. 77948 - 77957
(2015/09/28)
-
- Highly emissive organic solids with remarkably broad color tunability based on N,C-chelate, four-coordinate organoborons
-
Molecular fluorophores based on N,C-chelate, four-coordinate organoborons exhibit tunable solid-state emission colors that cover the whole visible region from blue to red. The emission color can be tuned through the substituents on either quinolines or the boron center.
- Shaikh, Aslam C.,Ranade, Dnyanesh S.,Thorat, Shridhar,Maity, Arunava,Kulkarni, Prasad P.,Gonnade, Rajesh G.,Munshi, Parthapratim,Patil, Nitin T.
-
supporting information
p. 16115 - 16118
(2015/11/10)
-
- Enantioselective cooperative triple catalysis: Unique roles of Au(i)/amine/chiral Bronsted acid catalysts in the addition/ cycloisomerization/transfer hydrogenation cascade
-
An enantioselective cooperative process involving the concerted/ simultaneous action of three different catalysts i.e. Au(i)/amine/chiral Bronsted acid catalysts has been realized for the synthesis of 2-substituted tetrahydroquinolines from 2-aminobenzaldehydes and terminal alkynes.
- Patil, Nitin T.,Raut, Vivek S.,Tella, Ramesh Babu
-
supporting information
p. 570 - 572
(2013/02/22)
-
- Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents
-
A simple, practical iron salt catalyzed procedure allows fast cross-couplings of N-heterocyclic chlorides and bromides with various electron-rich and -poor arylmagnesium reagents. A solvent mixture of THF and tBuOMe is found to be essential for achieving high yields mainly by avoiding homocoupling side reactions.
- Kuzmina, Olesya M.,Steib, Andreas K.,Knochel, Paul,Flubacher, Dietmar
-
supporting information
p. 4818 - 4821,4
(2012/12/12)
-
- Kumada-Tamao-Corriu coupling of heteroaromatic chlorides and aryl ethers catalyzed by (IPr)Ni(allyl)Cl
-
The complex (IPr)Ni(allyl)Cl (IPr = 1,3-bis(2,6-diisopropylphenyl) imidazolidene) catalyzes the cross-coupling reactions of heteroaromatic chlorides with aryl Grignard reagents. Catalyst loadings as low as 0.1 mol % have been used to afford the products in excellent yields. This nickel-based catalytic system also promotes the activation of the CAr-O bond of anisoles in the Kumada-Tamao-Corriu reaction under fairly mild conditions.
- Iglesias, Maria Jose,Prieto, Auxiliadora,Nicasio, M. Carmen
-
supporting information
p. 4318 - 4321
(2012/10/29)
-
- Catalytic arylation of a C-H bond in pyridine and related six-membered N-heteroarenes using organozinc reagents
-
Despite significant advances in the catalytic direct arylation of heteroarenes, the application of this reaction to pyridines has been met with limited success. An oxidative nucleophilic arylation strategy has been developed to overcome this problem. Pyridine, pyrazine, quinolone, and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using the developed nickel-catalyzed reaction. This protocol serves as a complementary method to catalytic direct arylation reactions. Less is more: Pyridine, pyrazine, quinoline and related electron-deficient N-heteroarenes can be arylated at the most electrophilic site using organozinc reagents through nickel catalysis. This protocol serves as a complementary method to catalytic direct arylation reactions. Copyright
- Hyodo, Isao,Tobisu, Mamoru,Chatani, Naoto
-
supporting information; experimental part
p. 1357 - 1365
(2012/08/08)
-
- Nickel-catalyzed reaction of arylzinc reagents with N-aromatic heterocycles: A straightforward approach to C-H bond arylation of electron-deficient heteroaromatic compounds
-
(Chemical Equation Presented) The reaction of electron-deficient N-heteroaromatic compounds, such as pyridines and quinolines, with arylzinc reagents in the presence of a catalytic amount of a nickel complex affords the arylated products. The reaction is likely to proceed through a formal nucleophilic 1,2-addition, thus exhibiting a reactivity complementary to conventional direct arylation through electrophilic substitution.
- Tobisu, Mamoru,Hyodo, Isao,Chatani, Naoto
-
supporting information; experimental part
p. 12070 - 12071
(2009/12/27)
-