160377-48-0

Basic information

• Product Name: 5-(4-IODOPHENYL)ISOXAZOLE
• Synonyms: 5-(4-IODOPHENYL)ISOXAZOLE;BUTTPARK 81\09-48
• CAS NO: 160377-48-0
• Molecular Formula: C9H6INO
• Molecular Weight: 271.05
• Mol File: 160377-48-0.mol

Chemical Properties

• Melting Point: 139 °C
• Boiling Point: 344.2 °C at 760 mmHg
• Flash Point: 162 °C
• Appearance: /
• Density: 1.773 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 5-(4-IODOPHENYL)ISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-IODOPHENYL)ISOXAZOLE(160377-48-0)
• EPA Substance Registry System: 5-(4-IODOPHENYL)ISOXAZOLE(160377-48-0)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 160377-48-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-IODOPHENYL)ISOXAZOLE is used as a building block for the synthesis of novel pharmaceutical compounds due to its unique chemical and biological properties imparted by the iodine substitution on the phenyl ring. This makes it a valuable asset in the development of new drugs with potential applications in various therapeutic areas.
Used in Medicinal Chemistry Research:
5-(4-IODOPHENYL)ISOXAZOLE is utilized as a research tool in medicinal chemistry for studying the structure-activity relationships of isoxazole derivatives and their potential pharmacological effects. Its unique properties can provide insights into the design and optimization of new drug candidates with improved efficacy and safety profiles.
Used in Drug Development:
5-(4-IODOPHENYL)ISOXAZOLE is employed in drug development as a starting material or intermediate for the synthesis of new compounds with potential therapeutic applications. Its presence in the molecular structure may contribute to the modulation of pharmacokinetic and pharmacodynamic properties, leading to the discovery of more effective and safer drugs.
Used in Antimicrobial Agents:
5-(4-IODOPHENYL)ISOXAZOLE is used as an antimicrobial agent, leveraging the antimicrobial activities of isoxazole derivatives. The iodine atom may enhance its ability to target and disrupt microbial cells, making it a potential candidate for the development of new antibiotics or antifungal agents.
Used in Anti-inflammatory and Analgesic Agents:
5-(4-IODOPHENYL)ISOXAZOLE is utilized in the development of anti-inflammatory and analgesic agents, capitalizing on the known anti-inflammatory and analgesic properties of isoxazole derivatives. The iodine substitution may further improve its efficacy and selectivity, offering a new avenue for the treatment of pain and inflammation.

InChI:InChI=1/C9H6INO/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H

Downstream Products

• 1428627-90-0 3,17β-bis(hydroxy)-7α-[6-(4-isoxazol-5-yl-phenyl)-hex-5-ynyl]estra-1,3,5(10)-triene 

Relevant articles and documents

Quinuclidine derivatives as squalene synthase inhibitors

Compounds of formula (I) and their pharmaceutically acceptable salts in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 are joined together so that CR1 -CR2 is a double bond; X is selected from --CH2 CH2 --, --CH=CH--, --C C--, --CH2 O--, --CH2 NH--, --NHCH2 --, --CH2 CO--, --COCH2 --, --CH2 S-- and --SCH2 --; Ar1 is a phenylene moiety; Ar2 is a heteroaryl moiety; and wherein one or both of Ar1 and Ar2 may optionally bear one or more substituents independently selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, di-alkylamino, N-alkylcarbamoyl, di-N,N-alkylcarbamoyl, alkoxycarbonyl, alkylthio, alkylsulphinyl, alkylsulphonyl, halogeno-alkyl, carboxyalkyl and alkanoylamino; provided that when R1 is hydroxy, X is not selected from --NHCH2 -- and --SCH2 --; are inhibitors of squalene synthase and hence useful in treating medical conditions in which a lowering of cholesterol is beneficial, such as hypercholesterolemia and atherosclerosis. Processes for preparing these derivatives, pharmaceutical compositions containing them are also described together with their use in medicine.