- Crystal form of phenol derivative and preparation method of crystal form
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The invention provides a crystal form of a phenol derivative and a preparation method of the crystal form and in particular provides a crystal form of a compound shown as the formula (I) and an isomer thereof, a preparation method and application of the crystal form to the medicine field. A structure is shown as the description.
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Paragraph 0072; 0073; 0074; 0075; 0076; 0077; 0078; 0079
(2017/04/21)
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- Isopropyl phenol derivative and its preparation method which has advantages of high reaction yield, high product purity, convenient post-treatment, and suitability for industrial mass production
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The present invention relates to an isopropyl phenol derivative and its preparation method, which, more particularly, relates to the preparation method for the compounds as shown by the formulae (I) and (IV) and their intermediates, and the intermediates. The disclosed method has advantages of high reaction yield, high product purity, convenient post-treatment, and suitability for industrial mass production.
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Page/Page column 32-33
(2017/07/01)
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- Process for producing ortho-isopropylated phenol derivatives
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This invention relates to the process for producing ortho-isopropylated phenol derivatives having following general formula (VIII). STR1 (in the above formula, R1 is a hydrogen or a low alkyl group of C1 -C4) A process for producing ortho-isopropylated phenol derivatives (VIII) of the present invention is characterized by obtaining position isomer desired by means of Claisen rearrangement of phenyl allyl ether without catalyst in atmosphere, and then obtaining only one isomer by oxidation and reduction of the above-obtained position isomer. According to the present invention, ortho-alkylated phenol derivatives (VIII) having high purity at low temperature and low pressure can be prepared without producing a by-product and requirement of the complicated separation procedure.
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