Sequential C3 and C5 direct C-H arylation of imidazo[1,2-a]pyrazines with (Hetero)aryl bromides
An efficient reaction manifold for the preparation of C3/C5- diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C-H functionalization event. Copyright
Johnson, Brett M.,Huestis, Malcolm P.
p. 1589 - 1593
(2014/03/21)
Sequential C3 and C5 Direct C-H Arylation of Imidazo[1,2-a]pyrazines with (Hetero)aryl Bromides
An efficient reaction manifold for the preparation of C3/C5-diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C-H functionalization event. An efficient reaction manifold for the preparation of C3/C5-diarylimidazo[1,2-a]pyrazines through sequential C3 and C5 direct arylation is disclosed. The two distinct palladium catalyst systems showcased herein are compatible with a wide variety of aryl and heteroaryl bromides and are also operative in a one-pot, twofold C-H functionalization event.
Johnson, Brett M.,Huestis, Malcolm P.
p. 1589 - 1593
(2015/10/05)
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