Syntheses of Antitumor Morphinane Alkaloids, Sinococuline and 6-epi-, 7-epi-, and 6-epi-7-epi-Sinococuline, from Sinomenine
An antitumor alkaloid, sinococuline 81), and its C-6 and/or C-7 epimeric analogs 3-5 have been synthesized from sinomenine (2).The carbonyl transposition from 9 to 8 using selenoxide chemistry proceeded in an efficient manner.Successive C-6 hydroxylation