Short and efficient preparations of isoxazole-3-carboxylic acid and imino-oxopentanoic acid potent precursors of 4-hydroxyisoleucine
Herein, we describe short and efficient syntheses of isoxazole-3-carboxylic acid 3a and imino-oxopentanoic acid 8 achiral precursors of 4-hydroxyisoleucine. The developed procedures involve readily available and cheap starting materials and can easily be
Becht, Jean-Michel,Marin, Sandra De Lamo,Maruani, Martine,Wagner, Alain,Mioskowski, Charles
Method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof
The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly
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(2010/11/23)
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