Synthesis of substituted coumarinyloxy triazoles and thiadiazoles and their antimicrobial activity
Hydrazides and thiosemicarbazides of substituted coumarins have been synthesised by condensing substituted carbethoxy coumarins with hydrazine hydrate and aryl isothiocyanates respectively.The thiosemicarbazides when cyclised on treatment with NaOH and conc.H2SO4 give triazoles and thiadiazoles.The synthesised compounds have been tested for their anti-microbial activity against Alternaria brassicicola, Fusarium udam, Staphylococcus gram (-ve), Lactobacilus gram (-ve).However none of them show any significant activity.
Bhavsar, S. B.,Shinde, D. B.,Shingare, M. S.
p. 70 - 74
(2007/10/02)
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