Unexpected beneficial effect of ortho -substituents on the (s)-proline-catalyzed asymmetric aldol reaction of acetone with aromatic aldehydes
An intriguing effect of electronegative 2,6-substituents on the stereochemical outcome of (S)-proline-catalyzed aldol reactions between benzaldehyde derivatives and acetone is reported. Remarkably high enantioselectivities can be achieved with such substrates. Georg Thieme Verlag Stuttgart New York.
Martínez, Alberto,Van Gemmeren, Manuel,List, Benjamin
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p. 961 - 964
(2014/05/06)
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