Derivatives of 4-amino-pyridine as selective thrombin inhibitors
During screening for novel thromin inhibitors it was discovered that the 4-aminopyridine derivative 1 inhibits human α-thrombin competitively and selectively. The 4-aminopyridine moiety itself is most likely the major determinant of the selectivity due to
Von der Saal, Wolfgang,Kucznierz, Ralf,Leinert, Herbert,Engh, Richard A.
p. 1283 - 1288
(2007/10/03)
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