16101-11-4 Usage
Uses
Used in Pharmaceutical Industry:
(+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole is used as a pharmaceutical agent for its anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
Used in Oncology:
In the field of oncology, (+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole is used as an anti-cancer agent, targeting and inhibiting the growth of cancer cells. Its potential application in this area is supported by its ability to exhibit anti-tumor effects and modulate various signaling pathways involved in cancer progression.
Used in Microbiology:
(+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole is utilized as an anti-microbial agent, effective against a range of microorganisms, including bacteria and fungi. Its application in this field aids in the treatment and prevention of infections caused by these pathogens.
Used in Cardiovascular Medicine:
(+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole is being researched for its potential use in cardiovascular medicine, where it may help in the treatment and management of various cardiovascular diseases by targeting specific molecular pathways involved in these conditions.
Used in Neurology:
In the field of neurology, (+)-2,3,4,6-tetrahydro-9-methoxy-1,2,5-trimethyl-1H-pyrido[4,3-b]carbazole is being explored for its potential use in the treatment of neurodegenerative disorders. Its application in this area is based on its ability to modulate neuroprotective pathways and potentially slow down the progression of these debilitating diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 16101-11-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,0 and 1 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16101-11:
(7*1)+(6*6)+(5*1)+(4*0)+(3*1)+(2*1)+(1*1)=54
54 % 10 = 4
So 16101-11-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H22N2O/c1-11-14-7-8-21(3)12(2)15(14)10-17-16-9-13(22-4)5-6-18(16)20-19(11)17/h5-6,9-10,12,20H,7-8H2,1-4H3
16101-11-4Relevant articles and documents
Synthesis and cytotoxic activity of hydroxylated derivatives of olivacine in relation with their biotransformation
Maftouh,Besselievre,Monsarrat,Lesca,Meunier,Husson,Paoletti
, p. 708 - 714 (2007/10/02)
The chemical synthesis of 9-hydroxyolivacine and 7-hydroxyolivacine based on a biomimetic approach is described. These two hydroxylated derivatives have been found as main in vitro metabolites of olivacine after incubation with rat hepatic microsomes. The pretreatment of animals with benzo[a]pyrene caused a large increase in both microsomal hydroxylations, whereas the pretreatment with phenobarbital caused a weak increase, with a preservation of 9-hydroxylation/7-hydroxylation ratio >1 in both cases. The two hydroxyolivacines have been also found as principal in vivo metabolites of olivacine in rat bile as glucuronide and sulfate conjugates. The pretreatment of animals with benzo[a]pyrene reverses the 9-hydroxyolivacine/7-hydroxyolivacine ratio excretion in bile to a value that is 1H NMR spectra. Hydroxylation at position 9 increases the in vitro cytotoxicity against leukemia L1210 cells (ID50 = 0.06 μM compared to 2.03 μM for olivacine) and an opposite effect is observed for hydroxylation at position 7 (ID50 = 12.8 μM). On the other hand, hydroxylation at position 9 has no effect on the in vivo antitumor activity against L1210. This might be related to the oxidative and conjugative metabolic pathways that play an important role in antitumor activity and deactivation of olivacine and its hydroxy metabolites.
