- Direct synthesis of quinazolinones by acceptorless dehydrogenative coupling of o-aminobenzamide and alcohols by heterogeneous Pt catalysts
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HBEA zeolite-supported Pt metal nanoclusters (Pt/HBEA) effectively catalyze direct dehydrogenative synthesis of quinazolinones from o-aminobenzamide and alcohols under promoter-free conditions. This is the first heterogeneous catalytic system for this reaction, which has a turnover number (TON) more than 25 times higher than previous homogeneous catalysts as well as wide scope for aliphatic and aromatic alcohols. This journal is the Partner Organisations 2014.
- Hakim Siddiki,Kon, Kenichi,Touchy, Abeda Sultana,Shimizu, Ken-Ichi
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- Method for synthesizing quinazolinone from anthranilamide and unsaturated aldehyde
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The invention discloses a method for synthesizing quinazolinone from anthranilamide and unsaturated aldehyde. The method comprises the steps: adding the quinazolinone, a transition metal catalyst, methylbenzene and the unsaturated adhehyde in a reaction container, making a reaction mixture react under 110 to 120 DEG C for 10 to 12 hours and cooling to room temperature; then separating to obtain atarget compound. According to the method disclosed by the invention, the anthranilamide and the unsaturated aldehyde which are easy to obtain are utilized as beginning raw materials, only water is generated as a byproduct in reaction, and reaction atom economy is high; thus, the reaction meets a green chemical requirement and has a wide development prospect.
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Paragraph 0098-0102
(2018/03/24)
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