- Synthesis and biological effects of new hybrid compounds composed of benzylguanidines and the alkylating group of busulfan on neuroblastoma cells
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131Iodine-labelled (meta-iodobenzyl)guanidine ([ 131I]-mIBG) and busulfan [butane-1,4-diylbis(methanesulfonate)] are well-established pharmaceuticals in neuroblastoma therapy. We report the design, synthesis, and testing of hybrid molecules - mBBG and pBBG - which combine key structural features of (meta-iodobenzyl)guanidine and busulfan: they contain a benzylguanidine moiety for accumulating in neuroblastoma cells via the noradrenaline transporter and, in the meta- or para-position, respectively, one of the two identical alkylating motives of busulfan for killing cells. Uptake and toxicity of hybrids mBBG and pBBG in human neuroblastoma cells compared favorably to their ancestors [131I]-mIBG and busulfan.
- Hampel, Thomas,Bruns, Marietta,Bayer, Melanie,Handgretinger, Rupert,Bruchelt, Gernot,Brückner, Reinhard
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