Synthesis of 4-thiothymine based photolabels as new tools for nucleic acids structural studies in solution: Formation of long-range photo-cross- links within a hammerhead ribozyme domain
The nucleosidic photolabels 2-5, able to form long-range photo-cross- links, have been used to further investigate the tertiary folding of a hammerhead ribozyme domain. These photolabels derive from 2'-deoxyuridine which is substituted at its C-5 position
Development of new nucleic acid photoaffinity probes: Synthesis of 4-thiothymine labelled nucleoside analogues
The new nucleic acid photoaffinity probes 1a, 1b, 2 and 3 in which a 4-thiothymine is linked at the end of a variable chain introduced at the C-5 position of deoxyuridine have been constructed.