- Allylic chlorination of terpenic olefins using a combination of MoCl 5 and NaOCl
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MoCl5 is applied as efficient agent in allylic chlorination of terpenic olefins in the presence of NaOCl as chlorine donor. Various terpenes are converted to the corresponding allylic chlorides in moderate to good yield under mild and optimized
- Boualy, Brahim,El Firdoussi, Larbi,Ali, Mustapha Ait,Karim, Abdellah
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- Synthesis of hybrid perillyl-4H-pyrans. Cytotoxicity evaluation against hepatocellular carcinoma HepG2/C3A cell line
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A series of 15 new hybrid perillyl-4H-pyrans compounds was straightforwardly synthesized by a strategy combining the multicomponent reaction and the copper-catalyzed alkyne-azide cycloaddition (CuAAC). The 2-amino-4H-pyrans-3-carbonitrile containing the a
- Guedes, Esthéfani P.,Mantovani, Mário S.,Marques, Lilian A.,Mass, Eduardo B.,Paczkowski, Ingrid M.,Russowsky, Dennis,de Meneses, Eliana W.
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- A family of chiral ionic liquids from the natural pool: Relationships between structure and functional properties and electrochemical enantiodiscrimination tests
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In spite of the increasing fundamental and practical interest of electrochemistry in ionic liquids (ILs), exploration of chiral ionic liquids (CILs) in view of enantioselective electrochemistry and electroanalysis is surprisingly overdue. In this study a
- Longhi, Mariangela,Arnaboldi, Serena,Husanu, Elena,Grecchi, Sara,Buzzi, Ivo Franco,Cirilli, Roberto,Rizzo, Simona,Chiappe, Cinzia,Mussini, Patrizia Romana,Guazzelli, Lorenzo
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p. 194 - 209
(2019/01/03)
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- Perilla amine compound and its preparation and use (by machine translation)
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The invention belongs to the field of medical technology, involves a series of formula I structure perilla amine compound and its preparation and use. The states the perilla amine compound includes pharmaceutically acceptable salts and solvates, and states the perilla amines containing the compound or its pharmaceutically acceptable salt as an active ingredient of the composition, can be used for treating cancer. The invention the perilla amine compounds and their pharmaceutically acceptable salts has better anti-cancer activity, its preparation method is simple and feasible, and easy to operate. (by machine translation)
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- Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activity
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A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid
- Vendrusculo, Vinicius,De Souza, Vanessa P.,M. Fontoura, Luiz Ant?nio,M. D'Oca, Marcelo G.,Banzato, Thais P.,Monteiro, Paula A.,Pilli, Ronaldo A.,De Carvalho, Jo?o Ernesto,Russowsky, Dennis
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p. 1553 - 1564
(2018/10/02)
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- A mild and efficient method for the synthesis of a new optically active diallyl selenide and its catalytic activity in the allylic chlorination of natural terpenes
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A mild and convenient method for the synthesis of a new optically active bis(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-ylmethyl)selenide 1 from the corresponding bicyclic terpene is described. The structure of the obtained organoselenium compound was establis
- Boualy, Brahim,El Houssame, Soufiane,Sancineto, Luca,Santi, Claudio,Ait Ali, Mustapha,Stoeckli-Evans, Helen,El Firdoussi, Larbi
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p. 3395 - 3399
(2016/05/09)
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- Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives
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Two series of amino-modified derivatives of (S)-perillyl alcohol were designed and synthesized using (S)-perillaldehyde as the starting material. These derivatives showed increased antiproliferative activity in human lung cancer A549 cells, human melanoma A375-S2 cells and human fibrosarcoma HT-1080 cells comparing with that of (S)-perillyl alcohol. Among these derivatives, compounds VI5 and VI7 were the most potent agents, with the IC50s below 100 μM. It was demonstrated that the antiproliferative effect of VI5 was mediated through the induction of apoptosis in A549 cells.
- Hui, Zi,Zhang, Meihui,Cong, Lin,Xia, Mingyu,Dong, Jinhua
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p. 6671 - 6682
(2014/06/10)
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- Novel limonene phosphonate and farnesyl diphosphate analogues: Design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors
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Limonene and its metabolite perillyl alcohol are naturally-occurring isoprenoids that block the growth of cancer cells both in vitro and in vivo. This cytostatic effect appears to be due, at least in part, to the fact that these compounds are weak yet sel
- Eummer, Jeffrey T.,Gibbs, Barbara S.,Zahn, Todd J.,Sebolt-Leopold, Judith S.,Gibbs, Richard A.
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p. 241 - 250
(2007/10/03)
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