161185-27-9Relevant articles and documents
Synthesis of Some Novel Heteroannulated Pyrano[3,2-c]quinoline-2,5(6H)-diones
Hassanin, Hany Mohamed,Abdel-Kader, Dalia
, p. 1685 - 1694 (2018)
6-Butyl-3-((dimethylamino)methylene)pyrano[3,2-c]quinolinone and 6-butyl pyrano[3,2-c]quinolone-3-carbonitrile were efficiently synthesized in good yield. These two new precursors were used to obtain some novel heteroannulated pyrano[3,2-c]quinolone derivatives from heterocyclization reactions with various binucleophiles. These heteroannulation reactions afforded novel heterocyclic systems fused to the pyranoquinolinone at face c, such as pyrazole, pyrimidine, pyridine, and pyrazolopyranone.
Syntheses of 3-Acyl-4-hydroxy-2(1H)-quinolones
Kappe, Thomas,Aigner, Rudolf,Hohengassner, Peter,Stadlbauer, Wolfgang
, p. 596 - 601 (2007/10/02)
3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyranoquinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3.Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)-quinolones 8.Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.