Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors
Nepodin and chrysophanol, isolated from Rumex nepalensis roots, showed significant cyclooxygenase (COX) inhibitory activity. To further optimize these lead molecules and study structure activity relationship (SAR), eighteen derivatives of nepodin and nine
Grover, Jagdeep,Kumar, Vivek,Singh, Vikram,Bairwa, Khemraj,Sobhia, M. Elizabeth,Jachak, Sanjay M.
p. 47 - 56
(2014/05/06)
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