Electrochemical cobalt-catalyzed C-H or N-H oxidation: A facile route to synthesis of substituted oxindoles
Two comparable protocols for the electrochemical cobalt-catalyzed C-H/N-H oxidation have been exploited for the synthesis of substituted oxindoles via radical pathways. The electrochemical cobalt-catalyzed system was demonstrated to be efficient and eco-friendly and avoided the use of stoichiometric oxidants to afford the arylation or alkylation products in good yields at room temperature.
Yu, Yue,Zheng, Peifeng,Wu, Yuanheng,Ye, Xiaoyi
supporting information
p. 8917 - 8921
(2018/12/10)
Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles
The first nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction for the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers is reported. A wide range of electrophiles, such as aryl iodides, bromides, triflates, and c
Copper-catalyzed Meerwein carboarylation of alkenes with anilines to form 3-benzyl-3-alkyloxindole
A simple and direct route for double C-C bond formation by copper-catalyzed Meerwein carboarylation process has been developed. In the presence of CuI (5 mol%), tert-butyl nitrite and anilines, a wide variety of N-arylacrylamides underwent tandem Meerwein arylation/C-H cyclization to produce pharmaceutically important 3-benzyl-3-alkyloxindole in moderate to good yield.
Copper-catalyzed bis-arylations of alkenes leading to oxindole derivatives
A simple and practical copper-catalyzed approach to oxindole derivatives by copper-catalyzed bis-arylation of N-alkyl-N-phenylacrylamides with diaryliodonium triflates has been developed under mild conditions, and the method is of tolerance towards some functional groups in the substrates. This journal is the Partner Organisations 2014.
Shi, Liangliang,Wang, Yuyuan,Yang, Haijun,Fu, Hua
supporting information
p. 4070 - 4073
(2014/06/10)
Metal-free meerwein carboarylation of alkenes with anilines: A straightforward approach to 3-benzyl-3-alkyloxindoles
A metal-free, straightforward carboarylation reaction of alkenes with anilines was developed that proceeds through a radical C-H cyclization. In the presence of benzoyl peroxide (5 mol-%), tert-butyl nitrite, and an array of anilines, a wide variety of N-arylacrylamides underwent a tandem Meerwein arylation/C-H cyclization to construct the pharmaceutically important 3-benzyl-3-alkyloxindole scaffold in moderate to good yields. Copyright
Tang, Shi,Zhou, Dong,Wang, Ying-Chun
supporting information
p. 3656 - 3661
(2014/06/23)
Copper-catalyzed oxidative electrophilic carbofunctionalization of acrylamides for the synthesis of oxindoles
A novel and efficient copper-catalyzed tandem oxidative cyclization of arylacrylamides with diaryliodonium salts is reported. This reaction provides a novel approach for the synthesis of oxindoles and various functional groups were well tolerated.
LCopper-catalyzed diarylation of activated alkenes with diaryliodonium salts
Cu(OTf)2-catalyzed diarylation of activated alkenes by using diaryliodonium(III) salts has been developed. With this method, arylated oxindoles can be easily accessed in good yields. Insights into the mechanism of copper-catalyzed arylations are discussed, and the findings are expected to help increase the level of understanding of catalytic arylations with diaryliodonium salts. Georg Thieme Verlag Stuttgart. New York.