Synthesis of Novel Fluoropicolinate Herbicides by Cascade Cyclization of Fluoroalkyl Alkynylimines
The cascade cyclization of fluoroalkyl alkynylimines with primary amines has been modified to allow the synthesis of 4-amino-5-fluoropicolinates. Use of N-trityl and acetal protecting groups in the cyclization precursor led to 5-fluoropyridines that were
Johnson, Peter L.,Renga, James M.,Galliford, Christopher V.,Whiteker, Gregory T.,Giampietro, Natalie C.
supporting information
p. 2905 - 2907
(2015/06/30)
PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6-(SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES
4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.
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Page/Page column
(2014/06/25)
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