A stereoselective approach to indolizidine and pyrrolizidine alkaloids: Total synthesis of (-)-lentiginosine, (-)-epi-lentiginosine and (-)-dihydroxypyrrolizidine
A simple and highly efficient approach to hydroxylated pyrrolizidine and indolizidine is developed from an aldehyde as a starting material using organocatalytic and asymmetric dihydroxylation reactions as key steps. Its application to the total synthesis of (-)-lentiginosine, (-)-epi-1,2- lentiginosine and (-)-dihydroxypyrrolizidine is also reported. the Partner Organisations 2014.