Synthesis and Antiretroviral Evaluation of 3-Alkyl 2-Piperazinone Nucleoside Analogs
Glycosylation of 3-alkyl N4-(3-hydroxypropyl) 2-piperazinones by ptotected 1-O-acetyl ribofuranoses produces nucleoside analogs in which the base is separated from the sugar by a hydrocarbon spacer arm.The preliminary in vitro test results against retroviruses seem promising for compounds bearing a long alkyl chain.