161602-47-7 Usage
Uses
Used in Organic Chemistry:
L-Alanine-3,3,3-d3,N-[(1,1-dimethylethoxy)carbonyl]is used as a reagent for the synthesis of amino acid derivatives. The deuterium atoms in the molecule can be used to study the kinetic isotope effect, which is important for understanding reaction mechanisms and improving synthetic methods.
Used in Peptide Synthesis:
L-Alanine-3,3,3-d3,N-[(1,1-dimethylethoxy)carbonyl]is used as a precursor for the synthesis of peptides. The t-BOC protecting group on the nitrogen atom prevents unwanted side reactions during peptide chain elongation, allowing for the selective incorporation of the deuterated L-Alanine residue into the peptide backbone. This can be useful for studying the structure and dynamics of peptides, as well as for the development of novel bioactive peptides with improved stability or altered biological activity.
Used in Pharmaceutical Research:
In the pharmaceutical industry, L-Alanine-3,3,3-d3,N-[(1,1-dimethylethoxy)carbonyl]can be used as a building block for the development of new drugs. The deuterium-labeled amino acid can be incorporated into drug candidates to study their metabolism, pharmacokinetics, and pharmacodynamics, potentially leading to the discovery of more effective and safer therapeutic agents.
Used in Analytical Chemistry:
L-Alanine-3,3,3-d3,N-[(1,1-dimethylethoxy)carbonyl]can be employed as an internal standard or a reference compound in various analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The presence of deuterium atoms in the molecule can help improve the accuracy and precision of these analytical methods, particularly when studying complex biological samples or when working with isotopically labeled compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 161602-47-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,6,0 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 161602-47:
(8*1)+(7*6)+(6*1)+(5*6)+(4*0)+(3*2)+(2*4)+(1*7)=107
107 % 10 = 7
So 161602-47-7 is a valid CAS Registry Number.
161602-47-7Relevant articles and documents
Synthesis of Amino Acid Derivatives Substituted in the Backbone with Stable Isotopes for Application in Peptide Synthesis
Lankiewicz, Leszek,Nyasse, Barthelemy,Fransson, Bengt,Grehn, Leif,Ragnarsson, Ulf
, p. 2503 - 2510 (2007/10/02)
Starting from the corresponding precursors, 1 and 2, the two well known procedures for asymmetric synthesis of amino acids, those of Schoellkopf and Oppolzer, were compared for the preparation of -labelled (substituted) Boc-leucine enantiomers.Although both gave the final products in comparable overall yields, analysis of optical purity by two independent chromatographic methods revealed that two procedures differed considerably in this respect.The enatiomeric excess found was 97.2 - 97.4 and 99.7percent, respectively.As a consequence, the latter method was preferred for the synthesis of a number of additional backbone-labelled Boc-derivatives of the three proteinogenic amino acids alanine, phenylalanine and tyrosine, including such deuteriated in the amino acid side-chain.These derivatives exemplify precursors suitable for chemical synthesis of specifically backbone-labelled peptides and should allow greater exploitation of the properties of the 13C and, especially, the 15N nuclei in structural studies.
