- Access to pyridyl-substituted 1,3,5-triazines from 4 H-pyrido[1,3]oxazin-4- ones via a cyclocondensation process
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Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin- 4-ones with amidines at room temperature or under microwave irradiations. The broad applicability was demonstrated by 33 examples with a variety of amidines and three different 4H-pyrido[1,3]oxazin-4-one chemical series. In addition, a one-pot process from 4H-pyrido[1,3]oxazin-4-one precursors (imide sodium salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in their global synthetic preparation. This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of application.
- Falher, Laetitia Le,Ben Ayad, Omar,Ziyaret, Ozge,Mamontov, Alexander,Botuha, Candice,Thorimbert, Serge,Slowinski, Franck
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p. 6579 - 6589
(2014/08/05)
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